A female runner in her 40s died Tuesday after suffering a medical emergency during the Cocodona 250, one of America’s most demanding ultramarathon races, according to local law enforcement and race officials.

First responders arrived at a trailhead in the Groom Creek community south of Prescott, Arizona, where the woman had collapsed during the 250-mile endurance event. Yavapai County Sheriff’s Office spokesperson Paul Wick confirmed the incident on Wednesday.

Erika Snyder, race codirector for the Cocodona 250, acknowledged the runner’s death but declined to release additional information at the family’s request. Race organizers expressed their condolences while announcing their decision to continue the event.

“Please keep the runner’s family, friends, fellow runners, volunteers, and first responders in your thoughts,” organizers stated. “We are deeply grateful to this beautiful community. The race is going to continue in their honor. We ask all participants and crew to carry the memory of this runner with you on the trail.”

The Cocodona 250 represents one of the most challenging ultramarathons in the United States. The course begins in Black Canyon City and winds through some of Arizona’s most renowned trails, including passages through Sedona, before concluding in Flagstaff. Runners face a daunting course that climbs more than a mile in elevation on two separate occasions. Participants have 125 hours to complete the journey.

While ultramarathons push human endurance to its limits, fatalities remain exceptionally rare given the growing number of participants worldwide. The sport has experienced significant growth in recent years, with races now held from Death Valley to the Himalayas. Last year, a Michigan woman collapsed and died during a 100-mile race in the mountains of southwest Colorado.

This year’s Cocodona 250 commenced Monday before dawn. Despite the tragedy, the race continued, and Rachel Entrekin crossed the finish line Wednesday afternoon to an enthusiastic crowd in Flagstaff, setting a new course record in the process.

The race’s increasing popularity has prompted organizers to implement a lottery registration system beginning next year. Throughout the course, aid stations provide runners with opportunities to refuel, hydrate, and adjust their equipment. Medical professionals are stationed at multiple points along the route, according to Snyder. The extreme nature of the event means participants often sleep on the ground during brief rest periods, as completing the course can take up to five days.

The incident serves as a sobering reminder of the physical demands placed on athletes who compete in ultra-endurance events, even as safety protocols and medical support continue to advance alongside the sport’s growth.

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