Law enforcement officials in Pima County, Arizona, are treating the disappearance of Nancy Guthrie, the 84-year-old mother of television personality Savannah Guthrie, as a criminal investigation after discovering blood evidence inside her Tucson home.

A source familiar with the case confirmed that investigators found a small amount of blood at the residence. The blood is currently undergoing testing to determine its origin. Forensic analysts continue to examine the home for additional clues that might explain the elderly woman’s whereabouts.

Pima County Sheriff Chris Nanos stated that investigators believe Nancy Guthrie was abducted from her home during the overnight hours this past weekend. The sheriff emphasized that the possibility of Guthrie wandering away from her residence has been ruled out, citing her limited mobility and the absence of any cognitive impairment.

The timeline of events presents a troubling picture. Guthrie was last observed at her home on Saturday evening. Her absence went unnoticed until Sunday morning when she failed to appear at church services, prompting concern among those who know her routine. She lives alone at the residence.

The urgency of the search has been heightened by the fact that Guthrie requires daily medication, according to Sheriff Nanos. Authorities have been actively searching for her since Sunday.

Her daughter, a co-host on a national morning television program, made a public appeal on social media Monday evening, requesting prayers for her mother’s safe return. In her statement, she described Nancy Guthrie as “a woman of deep conviction, a good and faithful servant,” and asked supporters to join the family in prayer during this difficult time.

The investigation has drawn support from 88-Crime, an Arizona-based nonprofit organization that assists law enforcement agencies in solving criminal cases. The organization announced it is offering a reward of up to $2,500 for information that leads to the arrest of any individual or individuals involved in the disappearance.

The case represents every family’s nightmare: an elderly parent, living independently, suddenly vanishing under circumstances that suggest foul play. The discovery of blood evidence transforms what might initially have been treated as a missing person case into something far more ominous.

As investigators continue their work, the family and community await answers. The combination of physical evidence, the victim’s limited mobility, and her regular habits all point toward an incident that Sheriff Nanos and his department are taking with the utmost seriousness.

Anyone with information regarding Nancy Guthrie’s disappearance is urged to contact local authorities immediately.

Related: Massachusetts Man Accidentally Destroys Home While Attempting to Remove Ice with Blowtorch